Probiotics are living bacteria found in the mouth, esophagus, stomach, gut, intestines, colon, and vaginal tract of mammals.  More than 400 bacterial species are found in the human digestive tract alone. Probiotics prevent the colonization of micro-organisms like pathogens. It is also linked to an increased resistance to infectious diseases, particularly of the intestine· decreased duration of diarrhea· reduction in blood pressure· reduction in serum cholesterol concentration· reduction in allergy· stimulation of phagocytosis by peripheral blood leucocytes· modulation of cytokine gene expression· adjuvant effect· regression of tumours· reduction in carcinogen or co-carcinogen production.  Schrezenmeir, J. and de Vrese, M.  2001. Probiotics, prebiotics, and synbiotics – approaching a definition. Am .J. Clin. Nutr. 73 (suppl):  361S-4S.  

Probiotics have been used with some benefit in the prevention and treatment of somegastrointestinal disorders, including antibiotic-associated diarrhea and some infectiousand viral diarrheas, most notably rotavirus-induced diarrhea, lactose intolerance,sucrase and maltase deficiencies and inflammatory bowel disease.

Probiotics are Gram positive bacteria and come in two basic classes; lactobacillus and bifidobacterium. Lactobaccili have a long history of use without risk to humans or animals. No pathogenic or virulence have been found for lactobacilli, bifidobacteria or lactococci (FAO/WHO Report 2001).

The vast majority of pet supplements don’t have any Probiotics in them. The few supplements with Probiotics contain only one - lactobacillus acidophilus.  Dr Krugers’s revolutionary in that it contains four Probiotics;

Lactobacillus acidophilus: Cleanses the intestinal wall of unfriendly bacteria, boosts immune system, management of diarrhea, anti-tumor, balances intestinal microbiota, and lowers fecal enzyme activity.

Enterococcus faecium: Used in the management of diarrheal illnesses often caused by antibiotic use. It is a bacterium that is important in the formation of fecal matter and is found in high concentration in feces.

 Loctobacillus cassei: Immune booster, lowers fecal enzyme activity, balances intestinal microbiota, tumor inhibitor, and complements the growth of Lactobacillus acidophilus. 

Lactobacillus Plantarum: Protective intestinal bacteria, involved in the production of several "gut nutrients," such as short-chain fatty acids, and the amino acids, arginine, cysteine, and glutamine. These beneficial bacteria may also help remove toxins from the gut and exert a beneficial effect on cholesterol levels. L. plantarum species has been tested clinically for its effect on irritable bowel syndrome (IBS) in humans. In these studies, subjects showed a decrease in IBS symptoms and reduced pain. 

Temperature: As Probiotics are living bacteria, they are temperature sensitive. Virtually all Probiotics sold have a threshold of 105 degrees Fahrenheit. So, if your Probiotic supplement sits in a truck on a hot summer day or in the cargo hold of a plane stuck on a hot runway, your Probiotics may be useless.   

Dr Krugers is revolutionary in that it uses new, more temperature-resistant Probiotics that have a threshold of 140 degrees. This way, we can guarantee that your Probiotics are potent no matter what time of year they were transported to your home or store. 

Digestive Enzymes – Min 1,000,000 CFU/gr (Amylase, Lipase, Cellulase, Protease)

Probiotics – Min 1,000,000 CFU/gr Enterococcus faecium, Lactobacillus Acidophilus, Loctobacillus cassei, lactobacillius planterum                                   

Digestive Enzymes: Digestive enzymes have only three main jobs; digesting protein, carbohydrates, and fat. Digestive enzymes help break down these complex sugars into simple sugars to make it easier to be absorbed in to the bloodstream. In order to function properly, digestive enzymes need the following chemical compounds to support them; Copper, magnesium, manganese, selenium, zinc, phosphorus. 

Dr Krugers contains these Digestive Enzymes and Enzyme Supporters:

Alpha-Amalyse:   Enzyme that helps digest starch.

Cellulase:   Enzyme that helps digest cellulose.

Lipase:   Enzyme that helps digest dietary fat.

Protease:   Enzyme that helps digest protein.

Enzyme Supporters:

Selenium:   Necessary for production for certain enzymes, works with Vitamin E in its functions and it helps reduce occurrences of cardiomyopothy.

Magnesium:   Necessary for the function of many enzymes and prevention of muscle tremors and convulsions.

Manganese:  Necessary for production of certain liver enzymes and production of blood cells.  

Zinc:  A component more than 300 enzymes that are needed to repair wounds, maintain fertility, protein synthesis, cell division (growth), preserve vision, boost immunity, and protect against free radicals, among other functions. Necessary for proper growth.Phosphorus:  A component of bone, teeth, nucleic acids and a number of enzymes and co-enzymes.  

Copper:  Component of many amino acids that is necessary for proper bone health, white blood cell production, and prevention of anemia.

Total:  6 enzyme supporters 

Dr Krugers Contains these Vitamins:  

Biotin:  Water-soluble B vitamin that helps metabolize protein, fats, and carbohydrates.  

Calcium:  Needed to form and keep strong bones and teeth.  

Choline: Needed for cell membrane integrity and to facilitate movement of fat in and out of cells. Also a component of the neurotransmitter acetylcholine and is needed for normal brain functioning (not technically a vitamin, but a compound-quaternary saturated amine – and an essential nutrient).  

Riboflavin:  Needed to process amino acids and fats, activate Vitamin B-6 and folic acid, and helps convert carbohydrates into ATP, the fuel the body runs on.  

Vitamin A:  Helps cells reproduce normally and prevent invasion by disease-causing microorganisms. Stimulates immunity and is needed for formation of bone, protein, and growth hormone.  

Vitamin B-1 (Thiamine):  Needed to process carbohydrates, fat, and protein. Every cell of the body requires vitamin B1 to form ATP-the fuel the body runs on. Nerve cells require vitamin B1 in order to function normally.   

Vitamin B-3 (Niacin):   Used to release energy from carbohydrates. Also needed to form fat from carbohydrates.  

Vitamin B-6 (Pyridoxine):   Needed  in processing of amino acids.   

Vitamin B-12:   Needed for normal nerve cell activity, DNA replication.  B-12 works with folic acid to control homocysteine levels.  Vitamin B12 deficiency can cause fatigue.  

Vitamin C (Ester C):  Functions as a powerful antioxidant. Needed to make collagen and plays an important role in wound healing and as a natural antihistamine. Aids in the formation of liver bile and helps to fight viruses and to detoxify the body.   

Vitamin D:  Maintains blood levels of calcium, which it accomplished by increasing absorption of calcium from food and reducing urinary calcium loss. Plays a role in immunity and blood cell formation.   

Vitamin E:   a powerful antioxidant that protects cell membranes 

Total: 12 vitamins.

Metals & Compounds:  

Cobalt:  Needed for myelin formation, the insulating layer found around nerves. Also supports red blood cell formation and is essential for metabolism of fats, carbohydrates and the synthesis of proteins and is a central component of the vitamin cobalamin, or vitamin B-12.  

Copper:  Component of many amino acids that is necessary for proper bone health, white blood cell production, and prevention of anemia.  

Iodine:   Needed to make thyroid hormones, which are necessary for maintaining normal metabolism in all cells of the body. Helps fire the brain synapses. Iodine deficiency causes goiter and is the leading cause of preventable mental retardation in humans.  

Iron:    Part of myoglobin, which helps muscle cells store oxygen. Without enough iron, ATP (the fuel the body runs on) cannot be properly synthesized. As a result, some iron deficient animals become fatigued even when their hemoglobin levels are normal.  

Magnesium:  Necessary for the function of many enzymes and prevention of muscle tremors and convulsions.   

Manganese:  Necessary for production of certain liver enzymes and production of blood cells.  

Potassium:  Needed to regulate water balance, levels of acidity, blood pressure, and neuromuscular function. It's also required for carbohydrate and protein metabolism.  

Selenium:   Necessary for production for certain enzymes, works with Vitamin E in its functions and it helps reduce occurrences of cardiomyopothy.    

Sodium:  Primary electrolyte that regulates cellular fluid levels and is essential for hydration.  

Sulfur:  Needed for the manufacture of many proteins, including those forming hair, muscles, and skin.   

Zinc:  A component more than 300 enzymes that are needed to repair wounds, maintain fertility, protein synthesis, cell division (growth), preserve vision, boost immunity, and protect against free radicals, among other functions. Necessary for proper growth.  

Cystine:  Chief sulfur containing component in protein molecules.  Without it, certain proteins could not be produced.   

Inositol:   Inositol is required for proper formation of cell membranes. It affects nerve transmission and helps in transporting fats within the body, a cyclic polyalcohol that plays an important role as a second messenger in a cell,   

Kelp:   A great source of iodine and trace minerals.  

dl-Methionine:  Carries sulfur and methyl groups necessary for normal metabolism.  

Phosphorus:  A component of bone, teeth, nucleic acids and a number of enzymes and co-enzymes.  

Total: 16

Acids: 

Fatty: Total: 4 fatty acids
 

Ceytl Myrisoleate:  An all natural medium chain fatty acid that acts as an anti inflammatory as well as a surfactant and lubricant to damaged joints.  

Whole Flaxseed:  Contains linoleic acid, an essential fatty acid needed for survival.  It also contains significant amounts of another essential fatty acid, alpha linolenic acid (ALA).  ALA is a omega-3 oil.  Promotes healthy skin and a shiny coat - Flaxseed is smaller than the head of a pin.  

Linolaic Acid:  An essential fatty acid required for the synthesis of cell membranes.   

Pantothenic Acid:   A constituent of Co-enzyme A which is a major part of long chain fatty acid compounds, and major metabolic reactions. 

Amino: Total: 8 Amino Acids
  

Folic Acid:   Required for production of several amino acid, creatine and choline and the production of DNA.  Prevents anemia.  

Glutamic Acid:   Helps maintain gastric acidity.  

Glycine:   Helps control muscle malfunction and abnormal nerve impulses – amino acid.  

Isoleucine:   An amino acid necessary for the optimum growth of young animals and for nitrogen balance in adults.  

Leucine:  An amino acid necessary for the optimum growth of young animals and for nitrogen balance in adults.  

Lysine:   An essential amino acid needed for growth and to help maintain nitrogen balance in the body.  

L-Threonine:   An amino aid that maintains proper protein balance in the body.  

Tyrosine:  An amino acid precursor to thyroid hormone and chetacholamines and melanine production.  Thyroid function is key to all other metabolism regulators.   

Total: 12 Acids

Bone Support:  

Chondroitin Sulfate:   A major constituent of cartilage, providing structure, holding water and nutrients, and allowing other molecules to move through cartilage-an important property, as there is no blood supply to cartilage.  

Glucosamine Sulphate:   Provides the joints with the building blocks they need to repair damage caused by arthritis, hip dysplasia or injuries.  The glucosamine sulfate form (stabilized with a mineral salt) has been the primary form used in the controlled trials of people with osteoarthritis. For this reason, it is the preferred form

Yucca, Devil’s Claw and Dandelion Root:  Helps with reducing inflammation in joints. 

Total: 5 Bone Support

Probiotics:  

Lactobacillus acidophilus: Cleanses the intestinal wall of unfriendly bacteria, boosts immune system, management of diarrhea, anti-tumor, balances intestinal microbiota, and lowers fecal enzyme activity. 

Enterococcus faecium: Used in the management of diarrheal illnesses often caused by antibiotic use. It is a bacterium that is important in the formation of fecal matter and is found in high concentration in feces. 

Loctobacillus cassei: Immune booster, lowers fecal enzyme activity, balances intestinal microbiota, tumor inhibitor, and complements the growth of Lactobacillus acidophilus. 

Lactobacillus Plantarum: Protective intestinal bacteria, involved in the production of several "gut nutrients," such as short-chain fatty acids, and the amino acids, arginine, cysteine, and glutamine. These beneficial bacteria may also help remove toxins from the gut and exert a beneficial effect on cholesterol levels. L. plantarum species has been tested clinically for its effect on irritable bowel syndrome (IBS). In these studies, subjects showed a decrease in IBS symptoms and reduced pain.

Total: 4 Probiotics